There are certain requirements that agriculture must meet to produce food and to keep producing food. We should view them as a hierarchy, such that if the top requirement is not attained, the lower requirements do not mean much, but once the top requirement has been met, we can move to the next one, provided that how we do it does not threaten any of the requirements above it. Each component is required, but not sufficient; all of them are needed.
If nature has not been optimized by any process that we know of, and therefore consists of mostly random mixes of species dictated primarily by natural disturbances, then there is no reason to “follow nature’s lead.” But if we don’t, what are we left with?
We are left with an agriculture based on human ingenuity.